Medalist ISPO 2021
| Medali | Bidang | Sekolah | Siswa 1 | Siswa 2 |
| Gold | Biologi | MAN 1 KUDUS | Fidia Aulia Nafis | Nadya Insyafana Rahma |
| Gold | Kimia | SMA Santa Laurensia | Janice Geraldine Chen | Rendi Orvalo Wijaya |
| Gold | Komputer | SMA Muhammadiyah 2 Surabaya | Muhammad Abyan Ermansyah Sungkar | Muhammad Syahnabil Hammam Sungkar |
| Gold | Lingkungan | SMA Kharisma Bangsa | Rizky Anatasha Halim | Adzwa Nuzayh Salim |
| Gold | Fisika | UPT SMP NEGERI 10 GRESIK | Nainis Laraswati | Muhamad Izzat Zaidan |
| Gold | Teknologi | SMA Negeri 1 Tarakan | Muhammad Faturrahman Marsuki | El Shinta |
| Silver | Biologi | SMP Pribadi Bilingual Boarding School | Najwa Azizah Ismail | |
| Silver | Biologi | MAN 2 Kota Malang | Safina Amelia Khansa | Hafidza Fatma Yona |
| Silver | Kimia | MAN 1 LAMONGAN | Ratna Eka Wulandari | Amaliya Putri |
| Silver | Komputer | SMA N 3 Semarang | Vondra Amabel Aryona | Afina Rahmantya |
| Silver | Lingkungan | SMAN 1 Sumbawa Besar | Muhammad Iqbal Taufiqur Rahman | Jane Chrisly Yongasa |
| Silver | Lingkungan | SMK AK Nusa Bangsa | Elisa Damayanti Putri | Rafi Irsyad Saputra |
| Silver | Fisika | MAN 2 Kudus | Anisa Nurmaharani | Tsabita Hasina Artanti |
| Silver | Teknologi | SMAN 1 Sumatera Barat | Raihan Adhipratama Arvi | |
| Silver | Teknologi | SMA Negeri 3 Bogor | Muhammad Farhan | |
| Bronze | Biologi | MAN 2 Kudus | Zahra Nisrina Dahlan | Kayyis Elya Salsabila |
| Bronze | Biologi | SMA Negeri 3 Yogyakarta | Aretha Putri | Masterino Wisam Wannawijaya |
| Bronze | Biologi | SMA Kharisma Bangsa | Aisyah Rifa Fadhilah | Muhamad Nabil Alhanif |
| Bronze | Kimia | SMA Negeri 7 Surabaya | Sabrina Khorina Pangestu | Ardilla Ayu Syahmina |
| Bronze | Kimia | SMAN 1 Salatiga | Zahra Aisya Rosa Febrianingtyas | Sabryna Fatikhatul Ramadhanty |
| Bronze | Komputer | SMA Negeri 8 Yogyakarta | Adzkiya Irbah | Rifka Noer Atmandita Sari |
| Bronze | Lingkungan | SMAK SANTU PETRUS | Jacky Felix | Senia Valensia |
| Bronze | Lingkungan | MAN 2 Kota Kediri | AQILA AISYA ADAMA | ZAKIAH DIAH ZULFIANI |
| Bronze | Lingkungan | Semesta Bilingual Boarding School | Fairuz Zahiya Meutia Dharmawan | Zahra Maulida Setya Andini |
| Bronze | Fisika | SMA GARUDA CENDEKIA | Faaiz Abdallah Dhewanto | Muhammad Akhtar Rashad |
| Bronze | Teknologi | MTsN 1 Kota Malang | Salwa Dilara Nandra Husada | Farsya Fahira Islami |
| Bronze | Teknologi | SMA Negeri 3 Bogor | Naufal Setyo Hema Wiratama | |
| Bronze | Teknologi | SMA Negeri 2 Depok | Laura Fawzia Sambowo | Naufal Ahmad Sanaya |
| HM | Biologi | SMA PGRI 2 Kayen | Arinda Kusumaningrum | Via Valenta Kafita Ardian |
| HM | Biologi | SMA Semesta Billingual Boarding School | Jelita Cinta Tariska Permatasari | Maharania Nasywa Supriadi |
| HM | Kimia | SMA NEGERI 3 SEMARANG | HASAN SHODIQ ALAYDRUS | CHANDRAKANTI LA FAINI PUTRI |
| HM | Kimia | Kharisma Bangsa | Mahaba Alifah Kadzima Eisya Galih Setiaji | |
| HM | Komputer | MAN 1 Lamongan | Kholilah Dwi Kartika Desi | Evi Wiyanti |
| HM | Komputer | MAN 1 LAMONGAN | Jasmine Suci Firdausy | Liza Ayu Dwi Kharisma |
| HM | Lingkungan | SMA Negeri 10 Bekasi | Clarissa Zefanya | Daniela Uli Putri Nugroho |
| HM | Lingkungan | SMA Negeri 1 Kota Bekasi | Ristya Cahyaningtyas | Yohana Magdalena Franklin Harianja |
| HM | Fisika | SMA NEGERI 1 KENDAL | Arif Pawoko | Rahma Ragil Khori’ah |
| HM | Fisika | MTsN 1 Kota Malang | Aqila Razzan Setyovianto | Fairuz Daffa Al Hazza |
| HM | Teknologi | MAN 1 Kudus | Alif Iklil Hilmy | |
| HM | Teknologi | SMK Ma’arif 1 Kebumen | RAHMAT TOHA MUFTI |
